KiTZ Data Commons is a web portal to simplify access to all data platforms that contain research data about pediatric cancer from KiTZ research studies. It provides an entry point to molecular profiles and clinical attributes from large-scale projects in pediatric cancer research.
The goal is to share these data as openly as possible with the pediatric research community (while adhering to all applicable data privacy laws) to support further biologic insights and translation into clinical applications.
This platform represents the access point for DNA methylation-based classification of central nervous system tumors.
cBioPortal for Cancer Genomics
The cBioPortal for Cancer Genomics is an open-access, open-source resource for interactive exploration of multidimensional cancer genomics data sets.
The "Pediatric Pan Cancer" (PedPanCan) study examines genetic alterations in childhood cancers at multiple levels. These include the analysis of structural variations, changes in copy number and small mutations. That allows the investigation of a possible druggability.
St. Jude PeCan Data Portal
PeCan provides interactive visualizations of pediatric cancer mutations across various projects at St. Jude Children's Research Hospital and its collaborators.
Online application Brain-Match provides visual interface for the comparison results of brain single cell data to pediatric neurooncology tumor materials with the main goal to detect possible cells-of-origin.
European Genome Phenome Archive
As part of the collaborative studies (Peifer et al. 2015, Ackermann et al. 2018) a large collection of whole genome sequencing, whole exome sequencing and RNA-sequencing data of neuroblastoma patient tumours is available upon request (accession numbers EGAS00001001308, EGAS00001003244).
Regulatory landscape of cells in the developing mouse cerebellum
Online application for the interactive exploration of cis-regulatory element (CRE) activity in cell types of the developing mouse cerebellum. Understanding the regulatory basis of healthy development can provide insights into the mechanisms leading to developmental disorders and pediatric brain tumors.