The Everest Centre for Low-grade Paediatric Brain Tumours

The EVEREST Center team

Low-grade brain tumours make up the largest group of tumours of the central nervous system in children, accounting for about half of all brain tumors in under-18s. In Germany and the UK combined, more than 400 children and adolescents are diagnosed every year. These tumours are caused by changes in the DNA that lead to uncontrolled growth of cells in the brain or spinal cord. The term ‘low-grade’ indicates that the tumours are relatively slow-growing, and the risk of their spreading to other parts of the body is low. Given their location, however, these tumours can still be very difficult to treat, with children often suffering life-long health problems as a result of their disease and/or from side-effects of the treatment.

At the new Everest Centre for Low-Grade Paediatric Brain Tumours, launched in Summer 2017, research groups from Heidelberg (KiTZ and DKFZ), Berlin and London are aiming to dramatically improve our understanding of the biology of low-grade childhood brain tumours, with the long-term goal of being able to develop new treatment approaches. The Brain Tumour Charity, based in the UK, is supporting the project together with almost 6 million Euros (£5mio) of funding from supporters of the Everest in the Alps team.

The Everest Centre got its name from this extraordinary fundraising campaign, through which the family and friends of Toby (a low-grade glioma patient) want to raise awareness and promote research for this disease, based on the personal experiences of his exhausting journey. In 2015, 2018 and again in 2019, a group of ski-tourers traversed the alps over four days until they had covered an elevation gain equivalent to the height of Mt Everest (8,848m) – a grueling physical (and mental!) challenge. You can read more about their efforts here. So far, their efforts have raised over £4 million for The Brain Tumour Charity - THANK YOU!!


The Everest Principal Investigators:

David T.W. Jones (KiTZ & DKFZ Heidelberg)
Stefan M. Pfister (KiTZ, DKFZ & University Hospital Heidelberg)
Olaf Witt (KiTZ, DKFZ & University Hospital Heidelberg)
David Capper (DKTK & Charité Berlin)
Denise Sheer (Blizard Institute, Queen Mary’s, University of London)
Tom Jacques (University College London/Great Ormond Street Hospital Institute of Child Health)
J-P Martinez-Barbera (University College London/Great Ormond Street Hospital Institute of Child Health)
Darren Hargrave (University College London/Great Ormond Street Hospital Institute of Child Health)


The EVEREST Newsletter for summer 22
The EVEREST Newsletter - Summer 2022 issue. Enjoy reading!
The EVEREST Newsletter for spring 22
The EVEREST Newsletter - Spring 2022 issue. Enjoy reading!
The EVEREST Newsletter for winter 21-22
The EVEREST Newsletter - Winter 2021/2022 issue. Enjoy reading!
Virtual EVEREST-Retreat, October 2021
The EVEREST Newsletter - Summer 2021 issue. Enjoy reading!
cakes of the big bake challenge
We have participated in the Big Bake Challenge 2021 at our monthly seminar series and raised oodles of dough for ‘The Brain Tumor Charity’ to help fight brain cancer. Our EVEREST community created very extraordinary cakes for our special seminar.
The EVEREST Centre for Low-Grade Paediatric Brain Tumour Research, Everest Newsletter Spring 2021
DFCI-Everest LGG Symposium, January 2020, Ladenburg.
International LGG Consensus Meeting, January 2020, Ladenburg.
Members of the Brain Tumour Charity and the Sagarmatha Team (Everest in the Alps 2019 challenge) visited us in Heidelberg in June 2019.
We strongly support the “Everest in The Alps” challenge!
The Everest Centre Team meeting at the Queen Mary BioEnterprises Innovation Centre and the Blizard Institute in London, UK (11.03.2019).
The Everest Centre Scientific Advisory Board Meeting, February 2018. From left-to-right, Everest Team unless otherwise noted: Michael Fisher (SAB member), David Jones, Stefan Pfister, Juliane Buhl, David Capper, Simone Schmidt, JP Martinez-Barbera, Nada Jabado (SAB member), Tom Jacques, Mark Kieran (SAB member), Tom Stone, Denise Sheer, Olaf Witt, Becky Birch (Brain Tumour Charity).

How tumour cell hibernation may affect the growth of low-grade brain tumours

Some of our most exciting findings to date are related to a cellular process called ‘oncogene-induced senescence’ (OIS). This is a mechanism in which some cells enter a dormant or hibernation state when they sense incorrect activation of a tumour-driving pathway, as a natural protective mechanism. We have known for some time that low-grade brain tumour cells often enter this dormant state, but not what might be controlling it or how it relates to overall tumour growth. We have now been able to show that chemicals released by the hibernating tumour cells are able to promote this state in their neighbours, and suppress tumour growth. Interestingly, we also saw that patients with high levels of this hibernation program in their tumour were less likely to experience a tumour recurrence – something which we now want to further test as part of an upcoming European clinical trial being led by us (the LOGGIC study). Finally, we found that a particular type of new drugs might be able to specifically kill these hibernating cells, which likely make up a large fraction of the cells in a typical low-grade brain tumour. This is important, because these dormant cells are often resistant to currently used chemotherapies, which typically kill only actively growing cells. We are now in the early stages of discussing how this could potentially be tested in a new Everest clinical trial concept.

A full list of scientific publications from our team members that have been financially supported through funding of the Everest Centre can be found at the bottom of this page.

In this video, MD student Maximilian Deng summarizes his latest work that was published in August 2020.
In this video, MD student Maximilian Deng gives us an update on some of the work he has been doing recently in the Jones lab.
In this video, we share with you the progress that has been done in 2019 by the Everest Team.


  1. Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases.
    Sievers P, Sill M, Schrimpf D, Friedel D, Sturm D, Gardberg M, Kurian KM, Krskova L, Vicha A, Schaller T, Hagel C, Abdullaev Z, Aldape K, Jacques TS, Korshunov A, Wick W, Pfister SM, von Deimling A, Jones DTW, Sahm F.
    Acta Neuropathol. 2022 Sep 7. doi: 10.1007/s00401-022-02492-7. Online ahead of print. PMID: 36070143

  2. BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.
    Selt F, Sigaud R, Valinciute G, Sievers P, Zaman J, Alco C, Schmid S, Peterziel H, Tsai JW, Guiho R, Martínez-Barbera JP, Pusch S, Deng J, Zhai Y, van Tilburg CM, Schuhman MU, Damaty AEL, Bandopadhayay P, Herold-Mende C, von Deimling A, Pfister SM, Montero J, Capper D, Oehme I, Sahm F, Jones DTW, Witt O, Milde T. Neuro Oncol. 2022 Aug 17:noac199. doi: 10.1093/neuonc/noac199. Online ahead of print. PMID: 35977048

  3. The first-in-class ERK inhibitor ulixertinib shows promising activity in MAPK-driven pediatric low-grade glioma models.
    Sigaud R, Rösch L, Gatzweiler C, Benzel J, von Soosten L, Peterziel H, Selt F, Najafi S, Ayhan S, Gerloff XF, Hofmann N, Büdenbender I, Schmitt L, Foerster KI, Burhenne J, Haefeli WE, Korshunov A, Sahm F, van Tilburg CM, Jones DTW, Pfister SM, Knoerzer D, Kreider BL, Sauter M, Pajtler KW, Zuckermann M, Oehme I, Witt O, Milde T. Neuro Oncol. 2022 Jul 27:noac183. doi: 10.1093/neuonc/noac183. Online ahead of print. PMID: 35882450

  4. Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC.
    Hasselblatt M, Thomas C, Federico A, Bens S, Hellström M, Casar-Borota O, Kordes U, Neumann JE, Dottermusch M, Rodriguez FJ, Lo AC, Cheng S, Hendson G, Hukin J, Hartmann C, Koch A, Capper D, Siebert R, Paulus W, Nemes K, Johann PD, Frühwald MC, Kool M. Neuropathol Appl Neurobiol. 2022 Jun;48(4):e12797. doi: 10.1111/nan.12797. Epub 2022 Feb 18. PMID: 35152461

  5. Rapid-CNS2: Rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study.
    Patel A, Dogan H, Payne A, Krause E, Sievers P, Schoebe N, Schrimpf D, Blume C, Stichel D, Holmes N, Euskirchen P, Hench J, Frank S, Rosenstiel-Goidts V, Ratliff M, Etminan N, Unterberg A, Dieterich C, Herold-Mende C, Pfister SM, Wick W, Loose M, von Deimling A, Sill M, Jones DTW, Schlesner M, Sahm F. Acta Neuropathol. 2022 May;143(5):609-612. doi: 10.1007/s00401-022-02415-6. Epub 2022 Mar 31. PMID: 35357562


  1. Pfister SM, Reyes-Múgica M, Chan JKC, Hasle H, Lazar AJ, Rossi S, Ferrari A,  Jarzembowski JA, Pritchard-Jones K, Hill AD, Jacques TS, Wesseling P, López Terrada D, von Deimling A, Kratz CP, Cree I, Alaggio R. A summary of the inaugural WHO Classification of Pediatric Tumors: Transitioning from the optical into the molecular era. Cancer Discovery. 2021 Dec 17. doi: 10.1158/2159-8290.CD-21-1094. PMID: 3492100

  2. Schmid S, Solomon DA, Perez E, Thieme A, Kleinschmidt-DeMasters BK, Giannini C, Reinhardt A, Asa SL, Mete O, Stichel D, Siewert C, Dittmayer C, Hasselblatt M, Paulus W, Nagel C, Harter PN, Schittenhelm J, Honegger J, Rushing E, Coras R, Pfister SM, Buslei R, Koch A, Perry A, Jones DTW, von Deimling A, Capper D, Lopes MB. Genetic and epigenetic characterization of posterior pituitary tumors. Acta Neuropathol. 2021 Dec;142(6):1025-1043. doi: 10.1007/s00401-021-02377-1. Epub 2021 Oct 18. PMID: 34661724

  3. Sievers P, Stichel D, Sill M, Schrimpf D, Sturm D, Selt F, Ecker J, Miele E, Kranendonk MEG, Tops BBJ, Kohlhof-Meinecke P, Beschorner R, Kramm CM, Hasselblatt M, Reifenberger G, Capper D, Wesseling P, Milde T, Korshunov A, Witt O, Pfister SM, Wick W, von Deimling A, Jones DTW,  Sahm F. Distribution of GOPC:ROS1 and other ROS1 fusions in glioma types. Acta Neuropathol. 2021 Sep. doi: 10.1007/s00401-021-02369-1. Online ahead of print. PMID: 34536122

  4. Alhalabi KT, Stichel D, Sievers P, Peterziel H, Sommerkamp AC, Sturm D, Wittmann A, Sill M, Jäger N, Beck P, Pajtler KW, Snuderl M, Jour G, Delorenzo M, Martin AM, Levy A, Dalvi N, Hansford JR, Gottardo NG, Uro-Coste E, Maurage CA, Godfraind C, Vandenbos F, Pietsch T, Kramm C, Filippidou M, Kattamis A, Jones C, Øra I, Mikkelsen TS, Zapotocky M, Sumerauer D, Scheie D, McCabe M, Wesseling P, Tops BBJ, Kranendonk MEG, Karajannis MA, Bouvier N, Papaemmanuil E, Dohmen H, Acker T, von Hoff K, Schmid S, Miele E, Filipski K, Kitanovski L, Krskova L, Gojo J, Haberler C, Alvaro F, Ecker J, Selt F, Milde T, Witt O, Oehme I, Kool M, von Deimling A, Korshunov A, Pfister SM, Sahm F, Jones DTW. PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta Neuropathol. 2021 Aug 21. doi: 10.1007/s00401-021-02354-8. Online ahead of print. PMID: 34417833
  5. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106. PMID: 34185076

  6. Schweizer L, Thierfelder F, Thomas C, Soschinski P, Kim HY, Jödicke R, Woltering N, Förster A, Teichmann D, Siewert C, Klein K, Schmid S, Nunninger M, Thomale UW, Onken J, Mühleisen H, Schittenhelm J, Tatagiba M, von Deimling A, Reuss DE, Solomon DA, Heppner FL, Koch A, Hartmann C, Staszewski O, Capper D. Molecular characterisation of sporadic endolymphatic sac tumours and comparison to von Hippel-Lindau disease-related tumours. Neuropathol Appl Neurobiol. 2021 Jun 5. doi: 10.1111/nan.12741. Online ahead of print. PMID: 34091929

  7. Milde T, Rodriguez FJ, Barnholtz-Sloan JS, Patil N, Eberhart CG, Gutmann DH. Reimagining Pilocytic Astrocytomas in the Context of Pediatric Low-Grade Gliomas.
    Neuro Oncol. 2021 Jun 16:noab138. Online ahead of print. PMID: 34131743

  8. Stichel D, Schrimpf D, Sievers P, Reinhardt A, Suwala AK, Sill M, Reuss DE, Korshunov A, Casalini BM, Sommerkamp AC, Ecker J, Selt F, Sturm D, Gnekow A, Koch A, Simon M, Hernáiz Driever P, Schüller U, Capper D, van Tilburg CM, Witt O, Milde T, Pfister SM, Jones DTW, von Deimling A, Sahm F, Wefers AK. Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data. Neuropathol Appl Neurobiol. 2021 Apr;47(3):406-414. doi: 10.1111/nan.12683. Epub 2021 Jan 17. PMID: 33336421

  9. Pickles JC, Mankad K, Aizpurua M, Paine SM, Bridges LR, Carceller F, Szychot E, Walker M, Fairchild AR, Mistry T, Ogunbiyi O, Rolland A, Stone TJ, Dryden C, Addy D, Garimberti E, Chalker J, Sahm F, Jones DT, Hargrave D, Jacques TS. A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC). Neuropathol Appl Neurobiol. 2021 Apr;47(3):464-467. doi: 10.1111/nan.12680. Epub 2021 Jan 12. PMID: 33325069

  10. Li YF, Scerif F, Picker SR, Stone TJ, Pickles JC, Moulding DA, Avery A, Virasami A, Fairchild AR, Tisdall M, Harkness W, Cross JH, Hargrave D, Guillemot F, Paine SM, Yasin SA, Jacques TS. Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis. Neuropathol Appl Neurobiol. 2021 Apr 2. PMID: 33797808

  11. Alves CAPF, Löbel U, Martin-Saavedra JS, Toescu S, Tsunemi MH, Teixeira SR, Mankad K, Hargrave D, Jacques TS, da Costa Leite C, Gonçalves FG, Vossough A, D'Arco F. A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study. AJNR. American Journal of Neuroradiology, 04 Mar 2021, 42(5):961-968. doi: 10.3174/ajnr.a7057. PMID: 33664107

  12. Chadda KR, Holland K, Scoffings D, Dean A, Pickles JC, Behjati S, Jacques TS, Trotman J, Tarpey P, Allinson K, Murray MJ. A rare case of paediatric astroblastoma with concomitant MN1-GTSE1 and EWSR1-PATZ1 gene fusions altering management. Genomics England Research Consortium. Neuropathology and Applied Neurobiology, 03 Feb 2021. doi: 10.1111/nan.12701. PMID: 33534137

  13. Hill CS, Khan M, Phipps K, Green K, Hargrave D, Aquilina K. Neurosurgical experience of managing optic pathway gliomas.
    Child's Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery, 03 Feb 2021, 37(6):1917-1929. doi: 10.1007/s00381-021-05060-8 PMID: 33532921

  14. Carreno G, Guiho R, Martinez-Barbera JP. Cell senescence in neuropathology: A focus on neurodegeneration and tumours. Neuropathology and Applied Neurobiology, 01 Feb 2021, 47(3):359-378. doi: 10.1111/nan.12689. PMID: 33378554

  15. Azizi AA, Walker DA, Liu JF, Sehested A, Jaspan T, Pemp B, Simmons I, Ferner R, Grill J, Hargrave D, Driever PH, Evans DG, Opocher E, SIOPE NF1 OPG Nottingham, UK, Workshop 2014. NF1 optic pathway glioma: analyzing risk factors for visual outcome and indications to treat. Neuro-oncology, 01 Jan 2021, 23(1):100-111. doi: 10.1093/neuonc/noaa153. PMID: 32628746


  1. Campion T, Quirk B, Cooper J, Phipps K, Toescu S, Aquilina K, Green K, Hargrave D, Mankad K. Surveillance imaging of grade 1 astrocytomas in children: can duration and frequency of follow-up imaging and the use of contrast agents be reduced? Neuroradiology, 25 Nov 2020, 63(6):953-958. doi: 10.1007/s00234-020-02609-3. PMID: 33241451

  2. Ernst KJ, Okonechnikov K, Bageritz J, Mallm J-P, Wittmann A, Maaß KK, Leible S, Boutros M, Pfister SM, Zuckermann M, Jones DTW. Establishment of a simplified preparation method for single-nucleus RNA-sequencing. and its application to long-term frozen tumor tissues. bioRxiv 2020.10.23.351809; doi: 10.1101/2020.10.23.351809

  3. Boonzaier NR, Hales PW, D'Arco F, Walters BC, Kaur R, Mankad K, Cooper J, Liasis A, Smith V, O'Hare P, Hargrave D, Clark CA. Quantitative MRI demonstrates abnormalities of the third ventricle subventricular zone in neurofibromatosis type-1 and sporadic paediatric optic pathway glioma. NeuroImage. Clinical, 28 Sep 2020, 28:102447. doi: 10.1016/j.nicl.2020.102447. PMID: 33038669

  4. Grabovska Y, Mackay A, O'Hare P, Crosier S, Finetti M, Schwalbe EC, Pickles JC, Fairchild AR, Avery A, Cockle J, Hill R, Lindsey J, Hicks D, Kristiansen M, Chalker J, Anderson J, Hargrave D, Jacques TS, Straathof K, Bailey S, Jones C, Clifford SC. Williamson D. Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity.
    Nature Communications, 28 Aug 2020, 11(1):4324. doi: 10.1038/s41467-020-18070-y. PMID: 32859926

  5. Selt F, van Tilburg CM, Bison B, Sievers P, Harting I, Ecker J, Pajtler KW, Sahm F, Bahr A, Simon M, Jones DTW, Well L, Mautner VF, Capper D, Hernáiz Driever P, Gnekow A, Pfister SM, Witt O, Milde T. Response to trametinib treatment in progressive pediatric low-grade glioma patients. J Neurooncol. 2020 Oct 7. doi: 10.1007/s11060-020-03640-3. Online ahead of print. PMID: 33026636

  6. Apps JR, Stache C, Gonzalez-Meljem JM, Gutteridge A, Chalker J, Jacques TS, Forshew T, Hölsken A, Martinez-Barbera JP. CTNNB1 mutations are clonal in adamantinomatous craniopharyngioma. Neuropathol Appl Neurobiol. 2020 Aug;46(5):510-514. doi: 10.1111/nan.12613. Epub 2020 Apr 2. PMID: 32125720

  7. Usta D, Sigaud R, Buhl JL, Selt F, Marquardt V, Pauck D, Jansen J, Pusch S, Ecker J, Hielscher T, Vollmer J, Sommerkamp AC, Rubner T, Hargrave D, van Tilburg CM, Pfister SM, Jones DTW, Remke M, Brummer T, Witt O, Milde T. A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells. Mol Cancer Ther. 2020 Aug;19(8):1736-1750. doi: 10.1158/1535-7163.MCT-19-1021. Epub 2020 May 25. PMID: 32451331

  8. Sommerkamp AC, Uhrig S, Stichel D, St-Onge P, Sun P, Jäger N, von Deimling A, Sahm F, Pfister SM, Korshunov A, Sinnett D, Jabado N, Wefers AK, Jones DTW. An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data. Acta Neuropathol. 2020 May 31. doi: 10.1007/s00401-020-02167-1. [Epub ahead of print] PMID: 32476062

  9. Pickles JC, Stone TJ, Jacques TS. Methylation-based algorithms for diagnosis: experience from neuro-oncology. J Pathol. 2020 Apr;250(5):510-517. doi: 10.1002/path.5397. Epub 2020 Mar 10. PMID: 32057098

  10. Guerrero A, Guiho R, Herranz N, Uren A, Withers DJ, Martínez-Barbera JP, Tietze LF, Gil J. Galactose-modified duocarmycin prodrugs as senolytics. Aging Cell. 2020 Apr;19(4):e13133. doi: 10.1111/acel.13133. Epub 2020 Mar 16. PMID: 32175667

  11. Martinez-Barbera JP, Andoniadou CL. Biological Behaviour of Craniopharyngiomas. Neuroendocrinology. 2020;110(9-10):797-804. doi: 10.1159/000506904. Epub 2020 Mar 4. PMID: 32126562

  12. Perez E, Capper D. Invited Review: DNA methylation-based classification of paediatric brain tumours. Neuropathol Appl Neurobiol. 2020 Feb;46(1):28-47. doi: 10.1111/nan.12598. Epub 2020 Feb 19. PMID: 31955441


  1. Deng MY, Sill M, Sturm D, Stichel D, Witt H, Ecker J, Wittmann A, Schittenhelm J, Ebinger M, Schuhmann MU, Figarella-Branger D, Aronica E, Staszewski O, Preusser M, Haberler C, Lauten M, Schüller U, Hartmann C, Snuderl M, Dunham C, Jabado N, Wesseling P, Deckert M, Keyvani K, Gottardo N, Giangaspero F, von Hoff K, Ellison DW, Pietsch T, Herold Mende C, Milde T, Witt O, Kool M, Korshunov A, Wick W, von Deimling A, Pfister SM, Jones DTW, Sahm F. Diffuse Glioneuronal tumour with Oligodendroglioma-like features and Nuclear Clusters (DGONC) - a molecularly-defined glioneuronal CNS tumour class displaying recurrent monosomy 14. Neuropathol Appl Neurobiol. 2019 Dec 23. doi: 10.1111/nan.12590. [Epub ahead of print] PMID: 31867747
  2. Jones DTW, Bandopadhayay P, Jabado N. The Power of Human Cancer Genetics as Revealed by Low-Grade Gliomas. Annu Rev Genet. 2019 Dec 3;53:483-503. doi: 10.1146/annurev-genet-120417-031642. [Review] PMID: 31794268
  3. Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J. Cardiac glycosides are broad-spectrum senolytics. Nat Metab. 2019 Nov;1(11):1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21. PMID: 31799499
  4. George SL, Izquierdo E, Campbell J, Koutroumanidou E, Proszek P, Jamal S, Hughes D, Yuan L, Marshall LV, Carceller F, Chisholm JC, Vaidya S, Mandeville H, Angelini P, Wasti A, Bexelius T, Thway K, Gatz SA, Clarke M, Al-Lazikani B, Barone G, Anderson J, Tweddle DA, Gonzalez D, Walker BA, Barton J, Depani S, Eze J, Ahmed SW, Moreno L, Pearson A, Shipley J, Jones C, Hargrave D, Jacques TS, Hubank M, Chesler L. A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations. Eur J Cancer. 2019 Nov;121:224-235. doi: 10.1016/j.ejca.2019.07.027. Epub 2019 Sep 19. PMID: 31543384
  5. Pickles JC, Fairchild AR, Stone TJ, Brownlee L, Merve A, Yasin SA, Avery A, Ahmed SW, Ogunbiyi O, Gonzalez Zapata J, Peary AF, Edwards M, Wilkhu L, Dryden C, Ladon D, Kristiansen M, Rowe C, Kurian KM, Nicoll JAR, Mitchell C, Bloom T, Hilton DA, Al-Sarraj S, Doey L, Johns PN, Bridges LR, Chakrabarty A, Ismail A, Rathi N, Syed K, Lammie GA, Limback-Stanic C, Smith C, Torgersen A, Rae F, Hill RM, Clifford SC, Grabovska Y, Williamson D, Clarke M, Jones C, Capper D, Sill M, von Deimling A, Pfister SM, Jones DTW, Hargrave D, Chalker J, Jacques TS. DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study. Lancet Child Adolesc Health. 2019 Nov 27. pii: S2352-4642(19)30342-6. doi: 10.1016/S2352-4642(19)30342-6. [Epub ahead of print] PMID: 31786093
  6. Sievers P, Schrimpf D, Stichel D, Reuss DE, Hasselblatt M, Hagel C, Staszewski O, Hench J, Frank S, Brandner S, Korshunov A, Wick W, Pfister SM, Reifenberger G, von Deimling A, Sahm F, Jones DTW. Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation. Acta Neuropathol. 2019 Nov 15. doi: 10.1007/s00401-019-02097-7. [Epub ahead of print]. PMID: 31729570
  7. Sievers P, Appay R, Schrimpf D, Stichel D, Reuss DE, Wefers AK, Reinhardt A, Coras R, Ruf VC, Schmid S, de Stricker K, Boldt HB, Kristensen BW, Petersen JK, Ulhøi BP, Gardberg M, Aronica E, Hasselblatt M, Brück W, Bielle F, Mokhtari K, Lhermitte B, Wick W, Herold-Mende C, Hänggi D, Brandner S, Giangaspero F, Capper D, Rushing E, Wesseling P, Pfister SM, Figarella-Branger D, von Deimling A, Sahm F, Jones DTW. Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1. Acta Neuropathol. 2019 Sep;138(3):497-504. doi: 10.1007/s00401-019-02038-4. Epub 2019 Jun 27. PMID: 31250151
  8. Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziède-Espariat A, Varlet P, Schwarz D, Söylemezoglu F, Pohl U, Pimentel J, Meyer J, Hewer E, Japp A, Joshi A, Reuss DE, Reinhardt A, Sievers P, Casalini MB, Ebrahimi A, Huang K, Koelsche C, Low HL, Rebelo O, Marnoto D, Becker AJ, Staszewski O, Mittelbronn M, Hasselblatt M, Schittenhelm J, Cheesman E, de Oliveira RS, Queiroz RGP, Valera ET, Hans VH, Korshunov A, Olar A, Ligon KL, Pfister SM, Jaunmuktane Z, Brandner S, Tatevossian RG, Ellison DW, Jacques TS, Honavar M, Aronica E, Thom M, Sahm F, von Deimling A, Jones DTW, Blumcke I, Capper D. Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta Neuropathol. 2019 Sep 28. doi: 10.1007/s00401-019-02078-w. [Epub ahead of print] PMID: 31563982
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