Preclinical, Translational, and Clinical Pediatric Oncology

Research for cures

KiTZ programs

The KiTZ is developing new diagnostic and therapeutic procedures to combat childhood cancer. This is only possible if research and clinic work hand in hand. To ensure this, the KiTZ is divided into three programs: clinical, translational and preclinical. As soon as the planned new building for the KiTZ has been erected, these areas of the KiTZ can move even closer together.

For more information on the KiTZ programs...
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Clinical Pediatric Oncology

The KiTZ program I "Clinical Pediatric Oncology" (headed by Prof. Dr. Andreas Kulozik) covers outpatient, day-clinic and in-patient clinical care as well as conducting clinical trials for our patients with cancer and severe blood diseases.

Focal points program I

  • Integral, age-appropriate therapy of children and adolescents with the entire spectrum of malignant diseases and severe non-malignant blood diseases
  • Leukemia: Novel approaches for treatment in close cooperation with the research group Muckenthaler

  • Osteosarcoma: Novel strategies of medicinal and local theraphy
    (see also: OSCAR heavy ion therapy)

  • Hemoglobin dieseases: Novel treatment concepts for patients suffering from thalassemia and sickle cell disease in the "Thalassemia and Sickle Cell Center Rhein-Neckar"

Prof. Dr. med. Andreas Kulozik, PhD

Director "Clinical Pediatric Oncology"

Postal address:
Clinic for Pediatric Oncology, Hematology, and Immunology
Center for Child and Adolescent Medicine
Jutta Mattern
Im Neuenheimer Feld 430
D-69120 Heidelberg

Translational Pediatric Oncology

The KiTZ program II "Translational Pediatric Oncology" (headed by Prof. Dr. Olaf Witt) comprises innovative individualized forms of treatment for children with malignant diseases. The focus is on the translation of new research findings into early clinical trials - especially for patients who did not benefit from established therapies. For this purpose, a study unit was set up at the KiTZ, the "KiTZ Clinical Trial Unit". There, young patients get access to new, targeted treatment options.

Focal points programm II

Prof. Dr. med. Olaf Witt

Director "Translational Pediatric Oncology"

Postal address:
German Cancer Research Center
CCU Pediatric Oncology / G340
Natja Sachse
Im Neuenheimer Feld 280
D-69120 Heidelberg


Preclinical Pediatric Oncology

The KiTZ program III "Preclinical Pediatric Oncology" (headed by Prof. Dr. Stefan Pfister) combines experimental pediatric oncology research groups from the DKFZ and the University Hospital. The aim is to develop new diagnostic methods for the classification of tumor diseases, to identify new mechanisms of tumorigenesis, and to derive therapeutic approaches from them. The researchers of the KiTZ pay particular attention to the identification and characterization of new genetic and epigenetic structures that could be associated with the development of childhood cancers. These will be used as targets for drug therapies or as diagnostic targets.

Focal points program III

  • Preclinical and translational research
  • Administration of the INFORM register
  • Molecular diagnostics, genome analysis for the
    • identification of novel therapies
    • specification of tumor diagnostics
    • individualization of therapy approaches

Prof. Dr. med. Stefan M. Pfister

Director "Preclinical Pediatric Oncology"

Postal address:
German Cancer Research Center
Div. Pediatric Neurooncology / B062
Ines Hofmann
Im Neuenheimer Feld 580
D-69120 Heidelberg