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LOGGIC Core

LGG registry

Pediatric low-grade glioma

LOGGIC Core

The LOGGIC Core BioClinical database (LOGGIC Core) is a registry of molecular and clinical data for pediatric low-grade gliomas (LGG). Since early 2019, patients have been recruited from an ever-increasing number of participating countries within and outside Europe.

Background information about low-grade gliomas

Low-grade gliomas (LGG) are a heterogeneous group of central nervous system (CNS) tumors classified as grade 1 and 2 tumors by the World Health Organization (WHO). The 10-year survival rate is over 90% and the probability of 10-year event-free survival is approximately 45%. This means that many patients suffer recurrent relapses and often receive multiple therapies. Many patients with LGG are only followed up closely after initial diagnosis or primary tumor resection. However, in several patients, the tumor is not resectable or not completely resectable and/or radiologically progressive and/or concurrent clinical symptoms are present. These chronically ill patients require - sometimes multiple - surgeries and additional non-surgical therapy.

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Objectives

LOGGIC Core data will be used to improve understanding of the tumor biology of the disease and to correlate molecular subsets of LGG with clinical courses, as well as to direct patients with tumors exhibiting appropriate molecular alterations to appropriate clinical trials.
Specifically, the database is expected to achieve the following goals:

  • Increase knowledge about genetic characteristics of LGGs.
  • Identification of targets that are potentially useful for therapies
  • Identification of biomarkers that can more accurately predict disease progression and response to chemo- and targeted therapies
  • Establishment of novel LGG tumor models to develop new therapeutic approaches

 

KiTZ Clinical Trial Unit (CTU)

German Cancer Research Center (DKFZ)

Heidelberg University Hospital

Dr. David T. W. Jones

Head of the Department of Pediatric Glioma Research
Hopp Children's Tumor Center Heidelberg (KiTZ)
German Cancer Research Center (DKFZ)

 

 

Prof. Dr. Olaf Witt

Director Translational Program, KiTZ
Head of the Clinical Cooperation Unit (KKE) Pediatric Oncology, DKFZ
Head of the KiTZ Clinical Trial Unit and Pediatric Brain Tumors
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital

 

 

Prof. Dr. med. Olaf Witt

Dr. Cornelis M. van Tilburg

KiTZ Clinical Trial Unit, KiTZ, DKFZ
Senior Physician - Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital
Medical Director Early Phase Clinical Trials
Medical Group Leader - Translational Clinical Trial Group

 

 

Dr. Pablo Hernáiz Driever

Study director national HIT-LOGGIC registry for children and adolescents with low-grade gliomas
Department of Pediatrics with focus on oncology and hematology
Charité - University Medicine Berlin

 

 

At KiTZ

Dr. David T. W. Jones
Head of the Department of Pediatric Glioma Research
Hopp Children's Tumor Center Heidelberg (KiTZ)
German Cancer Research Center (DKFZ)

Prof. Dr. Till Milde, MD
Senior physician - KiTZ Clinical Trial Unit
Group leader - Translational brain tumor modeling, KiTZ
KKE Pediatric Oncology, DKFZ
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital

Prof. Dr. Felix Sahm, MD und Prof. Dr. Andreas von Deimling, MD
Clinical Cooperation Unit (CCU) Neuropathology
Department of Neuropathology at the Institute of Pathology,
Heidelberg University Hospital

Dr. med. Kristian W. Pajtler, MBA
Group leader – Early Cancer Diagnostics & Reverse Translation, KiTZ
Division of Pediatric Neurooncology, DKFZ
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital

 

At Charité

Prof. Dr. David Capper, MD
Department of Neuropathology
Charité - Universitätsmedizin Berlin

PD Dr. Arend Koch, MD
Department of Neuropathology
Charité - Universitätsmedizin Berlin

Project management

Dr. Carina Bodden
KiTZ Clinical Trial Unit
Hopp Children's Tumor Center Heidelberg (KiTZ)
German Cancer Research Center (DKFZ)
Heidelberg University Hospital

Data management

Central Data Management of the Society for Oncology and Hematology (GPOH ZDM gGmbH)
c/o Hannover Medical School
Pediatric Oncology/Hematology

Funding

The Brain Tumour Charity (UK): The EVEREST Centre for Paediatric Low-Grade Brain Tumour Research

 

Cooperation partner

On an international level, there is a close cooperation with the SIOPE-BTG and on a national level with the national HIT LOGGIC Registry at the Charité-Universitätsmedizin Berlin for children and adolescents with low-grade gliomas. LOGGIC Core provides biological data that is used together with central clinical data to allow patients to enter (future) phase I/II/III trials.

 

If you have any further questions about the LOGGIC Core database, you can contact us via e-mail:

loggic(at)kitz-heidelberg.de